Nuclear localization of dengue virus nonstructural protein 5 does not strictly correlate with efficient viral RNA replication and inhibition of type I interferon signaling.

@article{Kumar2013NuclearLO,
  title={Nuclear localization of dengue virus nonstructural protein 5 does not strictly correlate with efficient viral RNA replication and inhibition of type I interferon signaling.},
  author={Anil Kumar and Sandra B{\"u}hler and Nicolas Papageorgiou and Andrew J Davidson and Klaas W. Mulder and Bruno Canard and Sven Miller and Ralf Bartenschlager},
  journal={Journal of virology},
  year={2013},
  volume={87 8},
  pages={4545-57}
}
Dengue virus (DENV) is an important human pathogen, especially in the tropical and subtropical parts of the world, causing considerable morbidity and mortality. DENV replication occurs in the cytoplasm; however, a high proportion of nonstructural protein 5 (NS5), containing methyltransferase (MTase) and RNA-dependent RNA polymerase (RdRp) activities, accumulates in the nuclei of infected cells. The present study investigates the impact of nuclear localization of NS5 on its known functions… CONTINUE READING
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Molecular basis for nucleotide conservation at the ends of the dengue virus genome

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