Nuclear localization of Schizosaccharomyces pombe Mcm2/Cdc19p requires MCM complex assembly.

@article{Pasion1999NuclearLO,
  title={Nuclear localization of Schizosaccharomyces pombe Mcm2/Cdc19p requires MCM complex assembly.},
  author={Sally G Pasion and Susan L. Forsburg},
  journal={Molecular biology of the cell},
  year={1999},
  volume={10 12},
  pages={
          4043-57
        }
}
The minichromosome maintenance (MCM) proteins MCM2-MCM7 are conserved eukaryotic replication factors that assemble in a heterohexameric complex. In fission yeast, these proteins are nuclear throughout the cell cycle. In studying the mechanism that regulates assembly of the MCM complex, we analyzed the cis and trans elements required for nuclear localization of a single subunit, Mcm2p. Mutation of any single mcm gene leads to redistribution of wild-type MCM subunits to the cytoplasm, and this… CONTINUE READING