Nuclear localization of Haa1, which is linked to its phosphorylation status, mediates lactic acid tolerance in Saccharomyces cerevisiae.

@article{Sugiyama2014NuclearLO,
  title={Nuclear localization of Haa1, which is linked to its phosphorylation status, mediates lactic acid tolerance in Saccharomyces cerevisiae.},
  author={Minetaka Sugiyama and Shin-Pei Akase and Ryota Nakanishi and Hitoshi Horie and Yoshinobu Kaneko and S. Harashima},
  journal={Applied and environmental microbiology},
  year={2014},
  volume={80 11},
  pages={3488-95}
}
Improvement of the lactic acid resistance of the yeast Saccharomyces cerevisiae is important for the application of the yeast in industrial production of lactic acid from renewable resources. However, we still do not know the precise mechanisms of the lactic acid adaptation response in yeast and, consequently, lack effective approaches for improving its lactic acid tolerance. To enhance our understanding of the adaptation response, we screened for S. cerevisiae genes that confer enhanced lactic… CONTINUE READING

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