Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein

@article{LopezGirona1999NuclearLO,
  title={Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein},
  author={Antonia Lopez-Girona and Beth Furnari and Odile Mond{\'e}sert and Paul Russell},
  journal={Nature},
  year={1999},
  volume={397},
  pages={172-175}
}
DNA damage activates a cell-cycle checkpoint that prevents mitosis while DNA repair is under way. The protein Chk1 enforces this checkpoint by phosphorylating the mitotic inducer Cdc25 (refs 2–6). Phosphorylation of Cdc25 by Chk1 creates a binding site in Cdc25 for 14-3-3 proteins, but it is not known how 14-3-3 proteins regulate Cdc25. Rad24 is a 14-3-3 protein that is important in the DNA-damage checkpoint in fission yeast. Here we show that Rad24 controls the intracellular distribution of… CONTINUE READING
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