Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation.

@article{Swift2013NuclearLS,
  title={Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation.},
  author={J. H. Swift and Irena L Ivanovska and Amnon Buxboim and Takamasa Harada and P. C. P. Dave Dingal and Joel Pinter and John David Pajerowski and Kyle R. Spinler and Jae-Won Shin and Manorama Tewari and Florian Rehfeldt and David W. Speicher and Dennis E Discher},
  journal={Science},
  year={2013},
  volume={341 6149},
  pages={1240104}
}
Tissues can be soft like fat, which bears little stress, or stiff like bone, which sustains high stress, but whether there is a systematic relationship between tissue mechanics and differentiation is unknown. Here, proteomics analyses revealed that levels of the nucleoskeletal protein lamin-A scaled with tissue elasticity, E, as did levels of collagens in the extracellular matrix that determine E. Stem cell differentiation into fat on soft matrix was enhanced by low lamin-A levels, whereas… CONTINUE READING
Highly Influential
This paper has highly influenced 34 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 22 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 336 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 47 references

Similar Papers

Loading similar papers…