Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation.

  title={Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation.},
  author={J. H. Swift and Irena L Ivanovska and Amnon Buxboim and Takamasa Harada and P. C. P. Dave Dingal and Joel Pinter and John David Pajerowski and Kyle R. Spinler and Jae-Won Shin and Manorama Tewari and Florian Rehfeldt and David W. Speicher and Dennis E Discher},
  volume={341 6149},
Tissues can be soft like fat, which bears little stress, or stiff like bone, which sustains high stress, but whether there is a systematic relationship between tissue mechanics and differentiation is unknown. Here, proteomics analyses revealed that levels of the nucleoskeletal protein lamin-A scaled with tissue elasticity, E, as did levels of collagens in the extracellular matrix that determine E. Stem cell differentiation into fat on soft matrix was enhanced by low lamin-A levels, whereas… CONTINUE READING
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