Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300.

  title={Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300.},
  author={Andrew E Horvai and Licen Xu and Edward Korzus and Gyan Brard and D A Kalafus and Traey Mullen and David W. Rose and Michael G. Rosenfeld and Christopher K. Glass},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={94 4},
We report that interferon gamma (IFN-gamma) inhibits transcription of the macrophage scavenger receptor gene by antagonizing the Ras-dependent activities of AP-1 and cooperating ets domain transcription factors, apparently as a result of competition between AP-1/ets factors and activated STAT1 for limiting amounts of CBP and p300. Consistent with this model, STAT1 alpha interacts directly with CBP in cells, and microinjection of anti-CBP and anti-p300 antibodies blocks transcriptional responses… CONTINUE READING
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