Nuclear import of the pre-integration complex (PIC): the Achilles heel of HIV?

@article{Piller2003NuclearIO,
  title={Nuclear import of the pre-integration complex (PIC): the Achilles heel of HIV?},
  author={Sabine C. Piller and Leon Caly and David Andrew Jans},
  journal={Current drug targets},
  year={2003},
  volume={4 5},
  pages={
          409-29
        }
}
Current treatments against the Aquired immune deficiency syndrome (AIDS) are reasonably effective in reducing the amount of human immunodeficiency virus (HIV) present in infected patients, but their side-effects, and the emergence of drug-resistant HIV strains have intensified the renewed search for novel anti-HIV therapies. An essential step in HIV infection is the integration of the viral genome into the host cell chromosomes within the nucleus. Unlike other retroviruses, HIV can transport… CONTINUE READING

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