Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylation.

@article{Drier1999NuclearIO,
  title={Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylation.},
  author={Eric A. Drier and Leslie H Huang and R. Steward},
  journal={Genes & development},
  year={1999},
  volume={13 5},
  pages={556-68}
}
In Drosophila, dorsal-ventral polarity is determined by a maternally encoded signal transduction pathway that culminates in the graded nuclear localization of the Rel protein, Dorsal. Dorsal is retained in the cytoplasm by the IkappaB protein, Cactus. Signal-dependent phosphorylation of Cactus results in the degradation of Cactus and the nuclear targeting of Dorsal. We present an in-depth study of the functional importance of Dorsal phosphorylation. We find that Dorsal is phosphorylated by the… CONTINUE READING
34 Citations
1 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

Similar Papers

Loading similar papers…