Nuclear import of microinjected influenza virus ribonucleoproteins.

  title={Nuclear import of microinjected influenza virus ribonucleoproteins.},
  author={Iris Kemler and Gary R. Whittaker and Ari Helenius},
  volume={202 2},
Influenza virus ribonucleoproteins (vRNPs) devoid of the matrix protein (M1) were isolated and introduced into the cytoplasm of CHO and MDCK cells by microinjection. The injected vRNPs were found to be imported into the nucleus, and the RNA was transcribed. Their uptake into the nucleus was ATP-dependent, inhibited by antibodies to the nuclear pore complex, unaffected by the prior acidification of the vRNPs, and not inhibited by amantadine. The results showed that for productive infection, all… CONTINUE READING
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