Nuclear import of a lipid-modified transcription factor: mobilization of NFAT5 isoform a by osmotic stress.

@article{Eisenhaber2011NuclearIO,
  title={Nuclear import of a lipid-modified transcription factor: mobilization of NFAT5 isoform a by osmotic stress.},
  author={Birgit Eisenhaber and Michaela Sammer and Wai Heng Lua and Wolfgang Benetka and Lai Ling Liew and Weimiao Yu and H. K. Lee and Manfred Koranda and Frank Eisenhaber and Sharmila Adhikari},
  journal={Cell cycle},
  year={2011},
  volume={10 22},
  pages={3897-911}
}
Lipid-modified transcription factors (TFs) are biomolecular oddities since their reduced mobility and membrane attachment appear to contradict nuclear import required for their gene-regulatory function. NFAT5 isoform a (selected from an in silico screen for predicted lipid-modified TFs) is shown to contribute about half of all endogenous expression of human NFAT5 isoforms in the isotonic state. Wild-type NFAT5a protein is indeed myristoylated and palmitoylated on its transport to the… CONTINUE READING
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