Nuclear import of CaMV P6 is required for infection and suppression of the RNA silencing factor DRB4.

@article{Haas2008NuclearIO,
  title={Nuclear import of CaMV P6 is required for infection and suppression of the RNA silencing factor DRB4.},
  author={Gabrielle Haas and Jacinthe Azevedo and Guillaume Moissiard and Ang{\`e}le Geldreich and Christophe Himber and Marina Bureau and Toshiyuki Fukuhara and Mario Keller and Olivier Voinnet},
  journal={The EMBO journal},
  year={2008},
  volume={27 15},
  pages={2102-12}
}
Replication of Cauliflower mosaic virus (CaMV), a plant double-stranded DNA virus, requires the viral translational transactivator protein P6. Although P6 is known to form cytoplasmic inclusion bodies (viroplasms) so far considered essential for virus biology, a fraction of the protein is also present in the nucleus. Here, we report that monomeric P6 is imported into the nucleus through two importin-alpha-dependent nuclear localization signals, and show that this process is mandatory for CaMV… CONTINUE READING
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