Nuclear import mechanism of the EJC component Mago-Y14 revealed by structural studies of importin 13.

@article{Bono2010NuclearIM,
  title={Nuclear import mechanism of the EJC component Mago-Y14 revealed by structural studies of importin 13.},
  author={Fulvia Bono and Atlanta G Cook and Marlene Gr{\"u}nwald and Judith Ebert and Elena Conti},
  journal={Molecular cell},
  year={2010},
  volume={37 2},
  pages={211-22}
}
Mago and Y14 are core components of the exon junction complex (EJC), an assembly central to nonsense-mediated mRNA decay in humans and mRNA localization in flies. The Mago-Y14 heterodimer shuttles between the nucleus, where it is loaded onto specific mRNAs, and the cytoplasm, where it functions in translational regulation. The heterodimer is imported back into the nucleus by Importin 13 (Imp13), a member of the karyopherin-beta family of transport factors. We have elucidated the structural… CONTINUE READING