Nuclear import and export signals enable rapid nucleocytoplasmic shuttling of the atypical protein kinase C lambda.

@article{Perander2001NuclearIA,
  title={Nuclear import and export signals enable rapid nucleocytoplasmic shuttling of the atypical protein kinase C lambda.},
  author={Maria Perander and Geir Bjorkoy and Terje Johansen},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 16},
  pages={
          13015-24
        }
}
The atypical protein kinase C (PKC) isoenzymes, lambda/iota- and zetaPKC, play important roles in cellular signaling pathways regulating proliferation, differentiation, and cell survival. By using green fluorescent protein (GFP) fusion proteins, we found that wild-type lambdaPKC localized predominantly to the cytoplasm, whereas both a kinase-defective mutant and an activation loop mutant accumulated in the nucleus. We have mapped a functional nuclear localization signal (NLS) to the N-terminal… CONTINUE READING
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