Nuclear import and export inhibitors alter capsid protein distribution in mammalian cells and reduce Venezuelan Equine Encephalitis Virus replication.

@article{Lundberg2013NuclearIA,
  title={Nuclear import and export inhibitors alter capsid protein distribution in mammalian cells and reduce Venezuelan Equine Encephalitis Virus replication.},
  author={Lindsay Lundberg and Chelsea Pinkham and Alan Baer and Moushimi Amaya and Aarthi Narayanan and Kylie M Wagstaff and David Andrew Jans and Kylene Kehn-Hall},
  journal={Antiviral research},
  year={2013},
  volume={100 3},
  pages={662-72}
}
Targeting host responses to invading viruses has been the focus of recent antiviral research. Venezuelan Equine Encephalitis Virus (VEEV) is able to modulate host transcription and block nuclear trafficking at least partially due to its capsid protein forming a complex with the host proteins importin α/β1 and CRM1. We hypothesized that disrupting the interaction of capsid with importin α/β1 or the interaction of capsid with CRM1 would alter capsid localization, thereby lowering viral titers in… CONTINUE READING

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