Nuclear hormone receptors enable macrophages and dendritic cells to sense their lipid environment and shape their immune response.

@article{Nagy2012NuclearHR,
  title={Nuclear hormone receptors enable macrophages and dendritic cells to sense their lipid environment and shape their immune response.},
  author={L{\'a}szl{\'o} Nagy and Attila Szanto and Istvan Szatmari and Lajos Sz{\'e}les},
  journal={Physiological reviews},
  year={2012},
  volume={92 2},
  pages={739-89}
}
A key issue in the immune system is to generate specific cell types, often with opposing activities. The mechanisms of differentiation and subtype specification of immune cells such as macrophages and dendritic cells are critical to understand the regulatory principles and logic of the immune system. In addition to cytokines and pathogens, it is increasingly appreciated that lipid signaling also has a key role in differentiation and subtype specification. In this review we explore how… CONTINUE READING
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