Nuclear hormone receptor coregulator: role in hormone action, metabolism, growth, and development.

@article{Mahajan2005NuclearHR,
  title={Nuclear hormone receptor coregulator: role in hormone action, metabolism, growth, and development.},
  author={Muktar A. Mahajan and Herbert H. Samuels},
  journal={Endocrine reviews},
  year={2005},
  volume={26 4},
  pages={583-97}
}
Nuclear hormone receptor coregulator (NRC) (also referred to as activating signal cointegrator-2, thyroid hormone receptor-binding protein, peroxisome proliferator activating receptor-interacting protein, and 250-kDa receptor associated protein) belongs to a growing class of nuclear cofactors widely known as coregulators or coactivators that are necessary for transcriptional activation of target genes. The NRC gene is also amplified and overexpressed in breast, colon, and lung cancers. NRC is a… CONTINUE READING

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