Nuclear hormone receptor co-repressors: Structure and function

@inproceedings{Watson2012NuclearHR,
  title={Nuclear hormone receptor co-repressors: Structure and function},
  author={Peter J. Watson and Louise Fairall and John W. R. Schwabe},
  booktitle={Molecular and Cellular Endocrinology},
  year={2012}
}
Co-repressor proteins, such as SMRT and NCoR, mediate the repressive activity of unliganded nuclear receptors and other transcription factors. They appear to act as intrinsically disordered "hub proteins" that integrate the activities of a range of transcription factors with a number of histone modifying enzymes. Although these co-repressor proteins are challenging targets for structural studies due to their largely unstructured character, a number of structures have recently been determined of… CONTINUE READING
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