Nuclear hormone receptor NR4A2 is involved in cell transformation and apoptosis.

@article{Ke2004NuclearHR,
  title={Nuclear hormone receptor NR4A2 is involved in cell transformation and apoptosis.},
  author={Ning Ke and Gisela Claassen and De-Hua Yu and Aaron E Albers and Wufang Fan and Philip Tak Wei Tan and Mirta Grifman and Xiuyuan Hu and Kristin Defife and Vivian Nguy and Bernd Meyhack and Arndt H Brachat and Flossie Wong-Staal and Qi-Xiang Li},
  journal={Cancer research},
  year={2004},
  volume={64 22},
  pages={
          8208-12
        }
}
HeLaHF cells are transformation revertants of cervical cancer HeLa cells and have lost anchorage-independent growth potential and tumorigenicity. Activation of tumor suppressor(s) was implicated previously in this transformation reversion. In this study, expression profiling analysis was carried out to identify potential oncogenes that are down-regulated in HeLaHF cells. We found that all three members of the NR4A1/Nur77/NGFIB orphan nuclear hormone receptor subfamily (NR4A1, NR4A2, and NR4A3… CONTINUE READING

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