Nuclear histones: major virulence factors or just additional early sepsis markers? A comment

Abstract

In 2009, Xu et al. and Chaput et al. in Nature Medicine had argued that the main cause of death in sepsis is the release from neutrophil nets of nuclear histone, highly toxic to endothelial cells and that these polycations are major and unique virulence factors. Since 2009, numerous researchers have also suggested the involvement of histones in the… (More)
DOI: 10.1007/s10787-016-0279-y

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