• Corpus ID: 119431048

Nuclear fusion enhances cancer cell killing efficacy in a protontherapy model

@article{Cirrone2017NuclearFE,
  title={Nuclear fusion enhances cancer cell killing efficacy in a protontherapy model},
  author={G A P Cirrone and Lorenzo Manti and Daniele Margarone and Lorenzo Giuffrida and Antonino Picciotto and Giacomo Cuttone and Georg Korn and V Marchese and G. Milluzzo and Giada Petringa and F. M. Perozziello and F Romano and Valentina Scuderi},
  journal={arXiv: Medical Physics},
  year={2017}
}
Protontherapy is hadrontherapy fastest-growing modality and a pillar in the battle against cancer. Hadrontherapy superiority lies in its inverted depth-dose profile, hence tumour-confined irradiation. Protons, however, lack distinct radiobiological advantages over photons or electrons. Higher LET (Linear Energy Transfer) $^{12}$C ions can overcome cancer radioresistance: DNA lesion complexity increases with LET, resulting in efficient cell killing, i.e. higher Relative Biological Effectiveness… 

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