Nuclear features of infiltrating urothelial carcinoma are distinguished from low-grade noninvasive papillary urothelial carcinoma by image analysis

  title={Nuclear features of infiltrating urothelial carcinoma are distinguished from low-grade noninvasive papillary urothelial carcinoma by image analysis},
  author={Noritake Kosuge and Masanao Saio and Hirofumi Matsumoto and Hajime Aoyama and Akiko Matsuzaki and Naoki Yoshimi},
  journal={Oncology Letters},
  pages={2715 - 2722}
Recent advances in computer technology have been made and image analysis (IA) has been introduced into pathological fields. The present study aimed to investigate the utility of IA for the evaluation of nuclear features and staining of immunohistochemistry (IHC) for Ki-67, p53 and GATA-binding protein 3 (GATA-3) in urothelial carcinoma tissue samples. A total of 49 cases of urothelial carcinoma tissue samples were obtained by transurethral resection of bladder tumors, which included 11 low… 
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Quantitative nucleic features are effective for discrimination of intraductal proliferative lesions of the breast
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Prospective analysis of Ki-67 as an independent predictor of oncologic outcomes in patients with high grade upper tract urothelial carcinoma.
Ki-67 over expression was associated with adverse pathological features in cases of upper tract urothelial carcinoma and was an independent predictor of recurrence-free survival in patients with high grade upper tract Urothelia carcinoma.
An International Ki67 Reproducibility Study in Adrenal Cortical Carcinoma
It is concluded that current practices in Ki67 scoring assessment vary greatly, and interobserver variation sets particular limitations to its clinical utility, especially around clinically relevant cutoff values.
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While the status of individual molecular markers does not add sufficient value to outcome prediction in patients with advanced urothelial carcinoma of the bladder, combinations of molecular markers may improve molecular staging, prognostication and possibly prediction of response to therapy.
GATA binding protein 3 is down-regulated in bladder cancer yet strong expression is an independent predictor of poor prognosis in invasive tumor.
A significant decrease in the expression of GATA binding protein 3 in urothelial neoplasms was seen and there were significant correlations between GATAbinding protein 3 expression vs androgen receptor overexpression, estrogen receptor α overexposure, or loss of estrogen receptor β expression.