Nuclear factories for signalling and repairing DNA double strand breaks in living fission yeast.

@article{Meister2003NuclearFF,
  title={Nuclear factories for signalling and repairing DNA double strand breaks in living fission yeast.},
  author={Peter Meister and Micka{\"e}l Poidevin and Stefania Francesconi and Isabelle Tratner and Patrick Zarzov and Giuseppe Baldacci},
  journal={Nucleic acids research},
  year={2003},
  volume={31 17},
  pages={5064-73}
}
In mammalian and budding yeast cells treated with genotoxic agents, different proteins implicated in detecting, signalling or repairing DNA lesions form nuclear foci. We studied foci formed by proteins involved in these processes in living fission yeast cells, which is amenable to genetic and molecular analysis. Using fluorescent tags, we analysed subnuclear localisations of the DNA damage checkpoint protein Rad9, of the homologous recombination protein Rad22 and of PCNA, which are implicated… CONTINUE READING
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