Nuclear factor of activated T cells c is a target of p38 mitogen-activated protein kinase in T cells.

@article{Wu2003NuclearFO,
  title={Nuclear factor of activated T cells c is a target of p38 mitogen-activated protein kinase in T cells.},
  author={Chia-Cheng Wu and S. C. Hsu and Hsiu-ming Shih and Ming-Zong Lai},
  journal={Molecular and cellular biology},
  year={2003},
  volume={23 18},
  pages={6442-54}
}
p38 mitogen activated protein kinase (MAPK) is essential for T-cell activation. Here we demonstrated that nuclear factor of activated T cells (NFAT) is a direct target of p38 MAPK. Inhibition of p38 MAPK led to selective inactivation of NFAT in T cells. We further linked a strict requirement of p38 MAPK to activation of NFATc. A stimulatory effect of p38 MAPK on at least four other stages of NFATc activation was found. First, the p38 MAPK cascade activated the NFATc promoter and induced the… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

Similar Papers

Loading similar papers…