Nuclear factor of activated T cells and early growth response-1 cooperate to mediate tissue factor gene induction by vascular endothelial growth factor in endothelial cells.

@article{Schabbauer2007NuclearFO,
  title={Nuclear factor of activated T cells and early growth response-1 cooperate to mediate tissue factor gene induction by vascular endothelial growth factor in endothelial cells.},
  author={Gernot A. Schabbauer and Bernhard Schweighofer and Diana Mechtcheriakova and Markus Lucerna and Bernd R. Binder and Erhard Hofer},
  journal={Thrombosis and haemostasis},
  year={2007},
  volume={97 6},
  pages={988-97}
}
Based on the finding that tissue factor belongs to a group of genes upregulated in endothelial cells by VEGF, but not by EGF, we investigated signals selectively triggered by VEGF. Whereas the transcription factor early growth response (EGR)-1, which has previously been shown by us to be essentially involved in tissue factor gene regulation, was similarly induced by both factors, one major difference between VEGF and EGF signaling was the activation of the Ca(++)-mediated calcineurin/nuclear… CONTINUE READING

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