Nuclear factor of activated T cells 5 regulates vascular smooth muscle cell phenotypic modulation.

@article{Halterman2011NuclearFO,
  title={Nuclear factor of activated T cells 5 regulates vascular smooth muscle cell phenotypic modulation.},
  author={Julia A. Halterman and Hyug Moo Kwon and Ramin Zargham and Pamela D Schoppee Bortz and Brian R. Wamhoff},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2011},
  volume={31 10},
  pages={2287-96}
}
OBJECTIVE The tonicity-responsive transcription factor, nuclear factor of activated T cells 5 (NFAT5/tonicity enhancer binding protein [TonEBP]), has been well characterized in numerous cell types; however, NFAT5 function in vascular smooth muscle cells (SMCs) is unknown. Our main objective was to determine the role of NFAT5 regulation in SMCs. METHODS AND RESULTS We showed that NFAT5 is regulated by hypertonicity in SMCs and is upregulated in atherosclerosis and neointimal hyperplasia. RNAi… CONTINUE READING
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