Nuclear factor-kappaB signaling contributes to severe, but not moderate, angiotensin II-induced left ventricular remodeling.

@article{Srmn2007NuclearFS,
  title={Nuclear factor-kappaB signaling contributes to severe, but not moderate, angiotensin II-induced left ventricular remodeling.},
  author={Bal{\'a}zs S{\'a}rm{\'a}n and R{\'e}ka Skoumal and Hanna Leskinen and Jaana Rys{\"a} and Mika Ilves and Ylermi M Soini and Juha Tuukkanen and Sampsa Pikkarainen and Zolt{\'a}n Lak{\'o}-Fut{\'o} and Beatrix S{\'a}rm{\'a}n and Lajos Papp and Rudolf deCh{\^a}tel and Mikl{\'o}s T{\'o}th and Heikki Ruskoaho and Istv{\'a}n Szokodi},
  journal={Journal of hypertension},
  year={2007},
  volume={25 9},
  pages={1927-39}
}
OBJECTIVE The transcription factor nuclear factor-kappaB (NF-kappaB) has been implicated in cardiomyocyte hypertrophy in vitro as well as in vivo; however, it is unknown if activation of NF-kappaB plays a mandatory role in the hypertrophic process. Here we characterize the importance of NF-kappaB signaling in moderate and severe left ventricular (LV) hypertrophy in rats with chronic pressure overload induced by angiotensin II (Ang II) infusion. METHODS AND RESULTS Electrophoretic mobility… CONTINUE READING
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