Nuclear factor-kappaB plays an essential role in the late phase of ischemic preconditioning in conscious rabbits.

@article{Xuan1999NuclearFP,
  title={Nuclear factor-kappaB plays an essential role in the late phase of ischemic preconditioning in conscious rabbits.},
  author={Y T Xuan and X L Tang and S Banerjee and H Takano and R C Li and H Han and Y Qiu and J J Li and R Bolli},
  journal={Circulation research},
  year={1999},
  volume={84 9},
  pages={1095-109}
}
  • Y T Xuan, X L Tang, +6 authors R Bolli
  • Published 1999 in Circulation research
Although it is recognized that late preconditioning (PC) results from upregulation of cardioprotective genes, the specific transcription factor(s) that govern this genetic adaptation remains unknown. The aim of this study was to test the hypothesis that the development of late PC is mediated by nuclear factor-kappaB (NF-kappaB) and to elucidate the mechanisms that control the activation of NF-kappaB after an ischemic stimulus in vivo. A total of 152 chronically instrumented, conscious rabbits… CONTINUE READING