Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor.

@article{Long2009NuclearFM,
  title={Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor.},
  author={Meixiao Long and Sung-Gyoo Park and Ian Strickland and Matthew S. Hayden and Sankar Ghosh},
  journal={Immunity},
  year={2009},
  volume={31 6},
  pages={921-31}
}
Naturally derived regulatory T (Treg) cells are characterized by stable expression of the transcription factor Foxp3 and characteristic epigenetic imprinting at the Foxp3 gene locus. Here, we found that enhancing nuclear factor (NF)-kappaB activity via a constitutive active inhibitor of kappaB kinase beta (IKKbeta) transgene in T cells led to increased number of Foxp3(+) cells in the thymus and can rescue Foxp3 expression in thymocytes deficient in other pleiotropic signaling molecules… CONTINUE READING
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