Nuclear factor-kappaB mediates simultaneous induction of inducible nitric-oxide synthase and Up-regulation of the cationic amino acid transporter CAT-2B in rat alveolar macrophages.

@article{Hammermann2000NuclearFM,
  title={Nuclear factor-kappaB mediates simultaneous induction of inducible nitric-oxide synthase and Up-regulation of the cationic amino acid transporter CAT-2B in rat alveolar macrophages.},
  author={Rainer Hammermann and Maria Donata Messeri Drei\ssig and Jutta M{\"o}ssner and Margarita Fuhrmann and Liberato Berrino and Manfred G{\"o}thert and Kurt Rack{\'e}},
  journal={Molecular pharmacology},
  year={2000},
  volume={58 6},
  pages={1294-302}
}
The connection between the regulation of L-arginine transport and nitric oxide (NO) synthesis was studied in rat alveolar macrophages. Lipopolysaccharides (LPSs) and interferon-gamma stimulated in the same concentration- and time-dependent manner NO synthesis (measured by nitrite accumulation) and L-[(3)H]arginine uptake. This correlated with an increased mRNA expression for iNOS and the cationic amino acid transporter CAT-2B (analyzed by reverse transcription-polymerase chain reaction), with… CONTINUE READING

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Mentioned Connections BETA
NF - kappaB is an essential transcription factor not only for the induction of iNOS , but also for the up - regulation of CAT-2B. The simultaneous up - regulation of CAT-2B with iNOS is considered as a mechanism to ensure a high substrate supply for iNOS .
TRANSCRIPTION FACTORIs biochemical function of gene productNF-kappa B
NF - kappaB is an essential transcription factor not only for the induction of iNOS , but also for the up - regulation of CAT-2B. The simultaneous up - regulation of CAT-2B with iNOS is considered as a mechanism to ensure a high substrate supply for iNOS .
NF - kappaB is an essential transcription factor not only for the induction of iNOS , but also for the up - regulation of CAT-2B. The simultaneous up - regulation of CAT-2B with iNOS is considered as a mechanism to ensure a high substrate supply for iNOS .
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