Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior.

@article{Koo2010NuclearFI,
  title={Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior.},
  author={Ja Wook Koo and Scott J Russo and Deveroux Ferguson and Eric J Nestler and Ronald S Duman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 6},
  pages={2669-74}
}
Proinflammatory cytokines, such as IL-1beta, have been implicated in the cellular and behavioral effects of stress and in mood disorders, although the downstream signaling pathways underlying these effects have not been determined. In the present study, we demonstrate a critical role for NF-kappaB signaling in the actions of IL-1beta and stress. Stress inhibition of neurogenesis in the adult hippocampus, which has been implicated in the prodepressive effects of stress, is blocked by… CONTINUE READING
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