Nuclear factor-kappaB inhibition improves myocardial contractility in rats with cirrhotic cardiomyopathy.

@article{Liu2008NuclearFI,
  title={Nuclear factor-kappaB inhibition improves myocardial contractility in rats with cirrhotic cardiomyopathy.},
  author={Hongqun Liu and Samuel Sangkon Lee},
  journal={Liver international : official journal of the International Association for the Study of the Liver},
  year={2008},
  volume={28 5},
  pages={640-8}
}
BACKGROUND/AIMS Cytokines such as tumour necrosis factor (TNF-alpha) contribute to the pathogenesis of cirrhotic cardiomyopathy. Nuclear factor-kappaB (NF-kappaB) is crucial for cytokine regulation, and induces cardiac dysfunction in several heart disease models. We aimed to elucidate possible NF-kappaB involvement in cirrhotic cardiomyopathy. METHODS Rats were bile duct ligated (BDL) to produce cirrhosis; controls received sham operation. Animals were studied 4 weeks later. Two NF-kappaB… CONTINUE READING