Nuclear factor-kappaB activation regulates cyclooxygenase-2 induction in human astrocytes in response to CXCL12: role in neuronal toxicity.

@article{lvarez2010NuclearFA,
  title={Nuclear factor-kappaB activation regulates cyclooxygenase-2 induction in human astrocytes in response to CXCL12: role in neuronal toxicity.},
  author={Susana {\'A}lvarez and Almudena Blanco and Manuel Rivas del Fresno and Ma {\'A}ngeles Mu{\~n}oz-Fern{\'a}ndez},
  journal={Journal of neurochemistry},
  year={2010},
  volume={113 3},
  pages={772-83}
}
Neurodegenerative and neuroinflammatory disorders are commonly associated with local chemokine release. In other way, emerging data indicate that the prostaglandin E2 (PGE(2)), one of the major prostaglandins produced in the brain, play a central role in several pathological diseases. In this study, we investigated the relationship between CXCL12, cyclooxygenase (COX)-2 and PGE(2) in human brain cells. CXCL12 induced COX-2 and secretion of PGE(2) in a dose-dependent manner in human astrocytes… CONTINUE READING

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