Nuclear factor-kappaB: a friend or a foe in cancer?

@article{Shishodia2004NuclearFA,
  title={Nuclear factor-kappaB: a friend or a foe in cancer?},
  author={Shishir Shishodia and Bharat Bhushan Aggarwal},
  journal={Biochemical pharmacology},
  year={2004},
  volume={68 6},
  pages={
          1071-80
        }
}
Nuclear transcription factor NF-kappaB, initially discovered as a factor in the nucleus of B cells that binds to the enhancer of the kappa light chain of immunoglobulin, has since been shown to be expressed ubiquitously in the cytoplasm of all cell types, conserved from Drosophila to man. It translocates to the nucleus only when activated, where it regulates the expression of over 200 genes that control the immune system, growth, and inflammation. The dysregulation of NF-kappaB can mediate a… CONTINUE READING

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