Nuclear factor kappa B signaling regulates neuronal morphology and cocaine reward.

  title={Nuclear factor kappa B signaling regulates neuronal morphology and cocaine reward.},
  author={Scott J Russo and Matthew B. Wilkinson and Michelle S Mazei-Robison and David M Dietz and Ian Maze and Vaishnav Krishnan and William Renthal and Ami R Graham and Shari G Birnbaum and Thomas A. Green and Bruce Robison and Alan Lesselyong and Linda I. Perrotti and Carlos A. Bola{\~n}os and Arvind Kumar and Michael S. G. Clark and John F. Neumaier and Rachael Lee Neve and Asha L. Bhakar and Phillip A Barker and Eric J Nestler},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={29 11},
Although chronic cocaine-induced changes in dendritic spines on nucleus accumbens (NAc) neurons have been correlated with behavioral sensitization, the molecular pathways governing these structural changes, and their resulting behavioral effects, are poorly understood. The transcription factor, nuclear factor kappa B (NFkappaB), is rapidly activated by diverse stimuli and regulates expression of many genes known to maintain cell structure. Therefore, we evaluated the role of NFkappaB in… CONTINUE READING


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