Nuclear factor-kappa B repression in antiinflammation and immunosuppression by glucocorticoids.

  title={Nuclear factor-kappa B repression in antiinflammation and immunosuppression by glucocorticoids.},
  author={Bart van der Burg and Johan Lid{\'e}n and Sam Okret and Franck Delaunay and Sacha Wissink and Paul T. van der Saag and J A Gustafsson},
  journal={Trends in endocrinology and metabolism: TEM},
  volume={8 4},
The transcription factor nuclear factor-kappaB (NF-kappaB) directs transcription of a large number of key molecules in immunological and inflammatory responses. The recently discovered inhibition of transcriptional activity of this factor by the activated glucocorticoid receptor (GR) provides a molecular basis for the potent antiinflammatory and immunosuppressive properties of glucocorticoids. This repressive activity of the GR can function independently of transcriptional activity. Because it… CONTINUE READING
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