Nuclear factor-kappa B mediates TNF-alpha inhibitory effect on alpha 2(I) collagen (COL1A2) gene transcription in human dermal fibroblasts.

@article{Kouba1999NuclearFB,
  title={Nuclear factor-kappa B mediates TNF-alpha inhibitory effect on alpha 2(I) collagen (COL1A2) gene transcription in human dermal fibroblasts.},
  author={David J Kouba and Kee Yang Chung and Toshio Nishiyama and Laurence Vindevoghel and Atsushi Kon and John F. Klement and Jouni Uitto and Alain Mauviel},
  journal={Journal of immunology},
  year={1999},
  volume={162 7},
  pages={4226-34}
}
Among its plethora of activities as an inflammatory mediator, TNF-alpha has potent regulatory control on extracellular matrix production and degradation. Earlier studies have documented that TNF-alpha inhibits type I collagen gene (COL1A2) expression at the transcriptional level, but the characterization of the transcription factors involved has been elusive. In the present study, using transient cell transfection of human dermal fibroblasts with a battery of 5' end deletion/chloramphenicol… CONTINUE READING
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