Nuclear factor-kappa B, cancer, and apoptosis.

  title={Nuclear factor-kappa B, cancer, and apoptosis.},
  author={Vincent Bours and Mohamed Bentires-Alj and Anne Cecile Hellin and Patrick Viatour and Pierre Robe and Sylvie Delhalle and Val{\'e}rie Beno{\^i}t and M P Merville},
  journal={Biochemical pharmacology},
  volume={60 8},
The role of nuclear factor (NF)-kappa B in the regulation of apoptosis in normal and cancer cells has been extensively studied in recent years. Constitutive NF-kappa B activity in B lymphocytes as well as in Hodgkin's disease and breast cancer cells protects these cells against apoptosis. It has also been reported that NF-kappa B activation by tumor necrosis factor (TNF)-alpha, chemotherapeutic drugs, or ionizing radiations can protect several cell types against apoptosis, suggesting that NF… CONTINUE READING


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