Nuclear factor-k B : a friend or a foe in cancer ?

  title={Nuclear factor-k B : a friend or a foe in cancer ?},
  author={Shishir Shishodia and Bharat Bhushan Aggarwal},
Nuclear transcription factor NF-kB, initially discovered as a factor in the nucleus of B cells that binds to the enhancer of the kappa light chain of immunoglobulin, has since been shown to be expressed ubiquitously in the cytoplasm of all cell types, conserved from Drosophila to man. It translocates to the nucleus only when activated, where it regulates the expression of over 200 genes that control the immune system, growth, and inflammation. The dysregulation of NF-kB can mediate a wide… CONTINUE READING
43 Citations
115 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 43 extracted citations


Publications referenced by this paper.
Showing 1-10 of 115 references

Evidence that activation of nuclear factor-kappa B is essential for doxorubicininduced cell death in myeloid and lymphoid cells

  • K Ashikawa, S Shishodia, I Fokt, W Priebe, BB. Aggarwal
  • Bochem Pharmacol
  • 2004
1 Excerpt

The RelA NF-kappaB subunit and the aryl hydro

  • DW Kim, L Gazourian, SA Quadri, R Romieu-Mourez, DH Sherr, GE. Sonenshein
  • Biochemical Pharmacology
  • 2004
1 Excerpt

Similar Papers

Loading similar papers…