Nuclear factor Y (NF-Y) and cellular senescence.

  title={Nuclear factor Y (NF-Y) and cellular senescence.},
  author={Koozi Matuoka and Kuang Yu Chen},
  journal={Experimental cell research},
  volume={253 2},
NF-Y, also termed CBF, is a major CCAAT-binding transcription factor that specifically recognizes the consensus sequence 5'-CTGATTGGYYRR-3 or 5'-YYRRCCAATCAG-3' (Y = pyrimidines and R = purines) present in the promoter region of many constitutive, inducible, and cell-cycle-dependent eukaryotic genes. The functional NF-Y is a heterotrimeric protein, consisting of three different subunits, A, B, and C. Each of the three subunits contains two or three distinct protein-interacting domains for… CONTINUE READING