Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine.

@article{Weerachayaphorn2012NuclearFF,
  title={Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine.},
  author={Jittima Weerachayaphorn and Albert Mennone and Carol J. Soroka and Kathy Harry and Lee R. Hagey and Thomas W Kensler and James L. Boyer},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2012},
  volume={302 9},
  pages={
          G925-36
        }
}
The transcription factor nuclear factor-E2-related factor 2 (Nrf2) is a key regulator for induction of hepatic detoxification and antioxidant mechanisms, as well as for certain hepatobiliary transporters. To examine the role of Nrf2 in bile acid homeostasis and cholestasis, we assessed the determinants of bile secretion and bile acid synthesis and transport before and after bile duct ligation (BDL) in Nrf2(-/-) mice. Our findings indicate reduced rates of biliary bile acid and GSH excretion… CONTINUE READING

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