Nuclear factor 90 mediates activation of the cellular antiviral expression cascade.

  title={Nuclear factor 90 mediates activation of the cellular antiviral expression cascade.},
  author={Irina Krasnoselskaya-Riz and Aliyah Spruill and Yi-Wen Chen and David M. Schuster and Theresa Teslovich and C G J Baker and Ajit Kumar and Dietrich A. Stephan},
  journal={AIDS research and human retroviruses},
  volume={18 8},
Viral infection triggers a cascade of interferon response genes, but the mechanisms that prime such innate antiviral defenses are poorly understood. Among candidate cellular mediators of the antiviral response are the double-stranded RNA (dsRNA)-binding proteins. Here we show that a C-terminal variant of the ubiquitous dsRNA-binding protein, nuclear factor 90 (NF90ctv), can activate the interferon response genes in the absence of viral infection. NF90ctv-expressing cells were infected with the… CONTINUE READING


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