Nuclear factor 1 is required for both hormone-dependent chromatin remodeling and transcriptional activation of the mouse mammary tumor virus promoter.

@article{Hebbar2003NuclearF1,
  title={Nuclear factor 1 is required for both hormone-dependent chromatin remodeling and transcriptional activation of the mouse mammary tumor virus promoter.},
  author={Pratibha B. Hebbar and Trevor K Archer},
  journal={Molecular and cellular biology},
  year={2003},
  volume={23 3},
  pages={887-98}
}
The mouse mammary tumor virus (MMTV) promoter has been used as a model to study how the glucocorticoid receptor (GR) remodels chromatin to allow other transcription factors to bind and activate transcription. To dissect the precise role of nuclear factor 1 (NF1) in chromatin remodeling and transcriptional activation, we used linker-scanning mutants of transcription factor binding sites on the MMTV promoter. We compared the NF1 mutant MMTV promoter in the context of transiently transfected… CONTINUE READING
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cocorticoid receptor - glucocorticoid response element binding stimulates nucleosome disruption by the SWI / SNF complex

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