Nuclear factor 1 and T-cell factor/LEF recognition elements regulate Pitx2 transcription in pituitary development.

@article{Ai2007NuclearF1,
  title={Nuclear factor 1 and T-cell factor/LEF recognition elements regulate Pitx2 transcription in pituitary development.},
  author={Di Ai and Jun Wang and Melanie Amen and Mei-fang Lu and Brad A Amendt and James F. Martin},
  journal={Molecular and cellular biology},
  year={2007},
  volume={27 16},
  pages={
          5765-75
        }
}
Pitx2, a paired-related homeobox gene that is mutated in Rieger syndrome I, is the earliest known marker of oral ectoderm. Pitx2 was previously shown to be required for tooth, palate, and pituitary development in mice; however, the mechanisms regulating Pitx2 transcription in the oral ectoderm are poorly understood. Here we used an in vivo transgenic approach to investigate the mechanisms regulating Pitx2 transcription. We identified a 7-kb fragment that directs LacZ expression in oral ectoderm… CONTINUE READING

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