Nuclear factor 1 (NF-1) binding sites in the genomes of human oncoviruses: a hypothetic role for reintegrated cellular origins of replication in malignant transformation.

@article{Minrovits1988NuclearF1,
  title={Nuclear factor 1 (NF-1) binding sites in the genomes of human oncoviruses: a hypothetic role for reintegrated cellular origins of replication in malignant transformation.},
  author={J{\'a}nos Min{\'a}rovits and Judit Segesdi and Zsuzsa Kov{\'a}cs and Istv{\'a}n F{\"o}ldes},
  journal={Medical hypotheses},
  year={1988},
  volume={25 1},
  pages={27-9}
}
We have found that genomes of human T cell leukemia-lymphoma virus type I (HTLV-I), BK virus (BKV), and a hepatitis B virus (HBV) DNA sequence integrated into DNA of a hepatoma-derived cell line contain binding sites for nuclear factor 1 (NF-1), a cellular protein which binds to adenoviral and putative cellular origins of DNA replication. We suggest that… CONTINUE READING