Nuclear factor κB up-regulation of CCAAT/enhancer-binding protein β mediates hepatocyte resistance to tumor necrosis factor α toxicity.

@article{Wang2010NuclearF,
  title={Nuclear factor κB up-regulation of CCAAT/enhancer-binding protein β mediates hepatocyte resistance to tumor necrosis factor α toxicity.},
  author={Yongjun Wang and Rajat Singh and Youqing Xiang and Linda E. Greenbaum and Mark J. Czaja},
  journal={Hepatology},
  year={2010},
  volume={52 6},
  pages={2118-26}
}
UNLABELLED The sensitization of hepatocytes to cell death from tumor necrosis factor α (TNFα) underlies many forms of hepatic injury, including that from toxins. Critical for hepatocyte resistance to TNFα toxicity is activation of nuclear factor κB (NF-κB) signaling, which prevents TNFα-induced death by the up-regulation of protective proteins. To further define the mechanisms of hepatocyte sensitization to TNFα killing, immunoblot analysis comparing livers from mice treated with… CONTINUE READING

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