Nuclear factor-κB regulates expression of platelet phospholipase C-β2 (PLCB2).

@article{Mao2016NuclearFR,
  title={Nuclear factor-κB regulates expression of platelet phospholipase C-β2 (PLCB2).},
  author={Guangfen Mao and Jianguo Jin and Satya P Kunapuli and A Koneti Rao},
  journal={Thrombosis and haemostasis},
  year={2016},
  volume={116 5},
  pages={931-940}
}
Phospholipase C (PLC)-β2 (gene PLCB2) is a critical regulator of platelet responses upon activation. Mechanisms regulating of PLC-β2 expression in platelets/MKs are unknown. Our studies in a patient with platelet PLC-β2 deficiency revealed the PLCB2 coding sequence to be normal and decreased platelet PLC-β2 mRNA, suggesting a defect in transcriptional… CONTINUE READING