Nuclear factor-κB contributes to neuron-dependent induction of glutamate transporter-1 expression in astrocytes.

@article{Ghosh2011NuclearFC,
  title={Nuclear factor-κB contributes to neuron-dependent induction of glutamate transporter-1 expression in astrocytes.},
  author={Mausam Ghosh and Yongjie Yang and Jeffrey D Rothstein and Michael B Robinson},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 25},
  pages={9159-69}
}
The glutamate transporter-1 [GLT-1 (excitatory amino acid transporter 2)] subtype of glutamate transporter ensures crisp excitatory signaling and limits excitotoxicity in the CNS. Astrocytic expression of GLT-1 is regulated during development, by neuronal activity, and in neurodegenerative diseases. Although neurons activate astrocytic expression of GLT-1, the mechanisms involved have not been identified. In the present study, astrocytes from transgenic mice that express enhanced green… CONTINUE READING