Nuclear factor {kappa}B inactivation in the rat liver ameliorates short term total warm ischaemia/reperfusion injury.

@article{Suetsugu2005NuclearF,
  title={Nuclear factor \{kappa\}B inactivation in the rat liver ameliorates short term total warm ischaemia/reperfusion injury.},
  author={H Suetsugu and Yuji Iimuro and Tetsuya Uehara and Toshihiro Nishio and Nobuko Harada and Masanori Yoshida and Etsuro Hatano and G. Bittolo Son and Jiro Fujimoto and Yoshio Yamaoka},
  journal={Gut},
  year={2005},
  volume={54 6},
  pages={835-42}
}
BACKGROUND In hepatic ischaemia/reperfusion injury, activated liver macrophages (Kupffer cells) are dominantly regulated by a transcription factor, nuclear factor kappaB (NFkappaB), with respect to expression of inflammatory cytokines, acute phase response proteins, and cell adhesion molecules. AIMS We assessed whether inactivation of NFkappaB in the liver could attenuate total hepatic warm ischaemia/reperfusion injury. METHODS We studied rats with hepatic overexpression of inhibitor… CONTINUE READING

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