Nuclear factor‐κB as a molecular target for migraine therapy

  title={Nuclear factor‐κB as a molecular target for migraine therapy},
  author={U. Reuter and A. Chiarugi and H. Bolay and M. Moskowitz},
  journal={Annals of Neurology},
  • U. Reuter, A. Chiarugi, +1 author M. Moskowitz
  • Published 2002
  • Medicine
  • Annals of Neurology
  • Nitric oxide (NO) generated from inducible NO synthase (iNOS) participates in immune and inflammatory responses in many tissues. The NO donor glyceryl trinitrate (GTN) provokes delayed migraine attacks when infused into migraineurs and also causes iNOS expression and delayed inflammation within rodent dura mater. Sodium nitroprusside, an NO donor as well, also increases iNOS expression. Because inflammation and iNOS are potential therapeutic targets, we examined transcriptional regulation of… CONTINUE READING
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