Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals

@inproceedings{Fung2017NuclearER,
  title={Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals},
  author={Ho Yee Joyce Fung and Szu-Chin Fu and Yuh Min Chook},
  booktitle={eLife},
  year={2017}
}
Nuclear export receptor CRM1 binds highly variable nuclear export signals (NESs) in hundreds of different cargoes. Previously we have shown that CRM1 binds NESs in both polypeptide orientations (Fung et al., 2015). Here, we show crystal structures of CRM1 bound to eight additional NESs which reveal diverse conformations that range from loop-like to all-helix, which occupy different extents of the invariant NES-binding groove. Analysis of all NES structures show 5-6 distinct backbone… CONTINUE READING
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